Advanced Biology: Molecular Biology & Biochemistry

Dual View: Evolutionary Claims vs. Intelligent Design Evidence

Grades 11-12 | Truth Carriers Academy

Table of Contents

1Biochemistry Foundations

RECEIVE - The Chemistry of Life

"And Yahuah Elohim formed man of the dust of the ground, and breathed into his nostrils the breath of life" - Genesis 2:7
Our bodies are made of common elements - but life itself comes from the Creator!

Four Major Biomolecules

TypeMonomersFunctionsExamples
CarbohydratesMonosaccharidesEnergy, structureGlucose, starch, cellulose
LipidsFatty acids, glycerolEnergy storage, membranesFats, phospholipids
ProteinsAmino acidsStructure, enzymes, transportHemoglobin, collagen
Nucleic AcidsNucleotidesGenetic informationDNA, RNA

EVIDENCE OF DESIGN: Carbon's Unique Properties

Carbon is the backbone of all life molecules because of its unique design:

No other element can do what carbon does. This is not coincidence - it's design!

REFLECT - Questions

1. What are the monomers of proteins?

2. Why is carbon uniquely suited for life?

2Protein Structure & Function

RECEIVE - The Workhorses of the Cell

Four Levels of Protein Structure

LevelDescriptionBonds/Forces
PrimaryAmino acid sequencePeptide bonds
SecondaryAlpha helix, beta sheetHydrogen bonds
Tertiary3D foldingMultiple interactions
QuaternaryMultiple polypeptidesSame as tertiary

20 Amino Acids

All proteins are made from just 20 amino acids, each with:

THE PROTEIN FOLDING PROBLEM

Proteins must fold into precise 3D shapes to function. This is a massive problem for evolution:

This is a chicken-and-egg problem that screams DESIGN!

REFLECT - Questions

1. How many amino acids are used to build proteins?

2. Why is protein folding a problem for naturalistic origins?

3Enzymes: Molecular Machines

RECEIVE - Biological Catalysts

Enzyme Properties

Lock and Key Model

Enzymes have an active site with a specific shape that fits the substrate like a lock and key.

Induced Fit Model: Active site molds slightly around substrate for better fit.

EVIDENCE OF DESIGN: Enzyme Specificity

Enzymes demonstrate incredible precision:

These are molecular machines with moving parts - designed systems!

REFLECT - Questions

1. What is the function of an enzyme?

4Advanced DNA Structure

RECEIVE - The Information Molecule

DNA Packaging

~2 meters of DNA packed into a nucleus 6 micrometers wide!

Types of DNA Sequences

TypeFunction
ExonsProtein-coding regions
IntronsRemoved during splicing - regulatory roles
PromotersControl gene expression
EnhancersBoost transcription from distance
TelomeresProtect chromosome ends

THE "JUNK DNA" MYTH - DEBUNKED

Evolutionists claimed 98% of DNA was "junk" - evolutionary leftovers.

The ENCODE Project (2012) showed:

Prediction confirmed: Design predicted function; evolution predicted junk!

REFLECT - Questions

1. What did the ENCODE project reveal about "junk DNA"?

5Gene Expression & Regulation

RECEIVE - How Genes Are Controlled

Levels of Gene Regulation

  1. Epigenetic: DNA methylation, histone modification
  2. Transcriptional: Transcription factors, promoters
  3. Post-transcriptional: RNA processing, miRNA
  4. Translational: Ribosome binding efficiency
  5. Post-translational: Protein modification, degradation

Epigenetics

Heritable changes in gene expression without changing DNA sequence:

EVIDENCE OF DESIGN: The Regulatory Network

Gene regulation is like a vast computer program:

Same DNA, different cell types - programmed by an intelligent system!

REFLECT - Questions

1. What is epigenetics?

6Molecular Genetics Techniques

RECEIVE - Tools of the Trade

Common Techniques

TechniquePurpose
PCRAmplify (copy) DNA segments
Gel ElectrophoresisSeparate DNA/proteins by size
DNA SequencingDetermine nucleotide order
CRISPREdit specific genes
Western/Northern/Southern BlotDetect specific proteins/RNA/DNA

CRISPR-Cas9 Gene Editing

"And Elohim saw every thing that He had made, and, behold, it was very good." - Genesis 1:31
Should we be editing what Yahuah called "very good"? Wisdom is needed.

REFLECT - Questions

1. What does PCR do?

7Cell Signaling

RECEIVE - How Cells Communicate

Signal Transduction Pathway

  1. Signal: Ligand (hormone, growth factor) released
  2. Reception: Ligand binds receptor protein
  3. Transduction: Signal cascades through proteins
  4. Response: Cell changes behavior (gene expression, metabolism)

Types of Signaling

EVIDENCE OF DESIGN: Signal Cascades

Cell signaling pathways are like complex electronic circuits:

This is systems engineering at the molecular level!

REFLECT - Questions

1. What are the four steps of signal transduction?

8The Immune System

RECEIVE - Yahuah's Defense System

Innate vs. Adaptive Immunity

InnateAdaptive
Fast response (minutes)Slower (days)
Non-specificHighly specific
No memoryHas memory
Barriers, phagocytes, inflammationB cells, T cells, antibodies

Antibody Diversity

Your body can make ~10 billion different antibodies!

EVIDENCE OF DESIGN: The Immune System

This coordinated system had to be complete from the beginning!

REFLECT - Questions

1. How many different antibodies can your body make?

9Irreducible Complexity

RECEIVE - Systems That Can't Evolve Gradually

Definition

Irreducible Complexity: A system that requires all parts to be present simultaneously to function. Remove any part and the system fails.

Analogy: A mousetrap - remove any component and it doesn't catch mice!

EXAMPLES OF IRREDUCIBLE COMPLEXITY

SystemComponents Needed
Bacterial Flagellum~40 protein parts (motor, rod, hook, filament)
Blood Clotting~20+ proteins in cascade
Cilium~200+ proteins
ATP SynthaseRotor, stator, shaft, proton channels
VisionLens, retina, optic nerve, visual cortex

THE BACTERIAL FLAGELLUM

A literal outboard motor with:

Remove any part = no function. How could this evolve step by step?

REFLECT - Questions

1. What is irreducible complexity?

10Information Theory & DNA

RECEIVE - The Information Argument

DNA as Information

DNA is not just chemistry - it's a code carrying information:

THE INFORMATION PROBLEM FOR EVOLUTION

Key insight: Information always comes from intelligence!

Question: Where did the information in the first genome come from?

SPECIFIED COMPLEXITY

DNA exhibits specified complexity:

Random text is complex but not specified. "HELP" written in sand is specified - and implies intelligence!

DNA is both complex AND specified = hallmark of design!

REFLECT - Questions

1. Why does information always require intelligence?

11Origin of Life Problem

RECEIVE - The Impossible Beginning

WHAT TEXTBOOKS TEACH

Life arose from non-living chemicals through natural processes. The Miller-Urey experiment showed amino acids can form naturally. Given enough time, self-replicating molecules emerged.

WHAT SCRIPTURE SAYS

"All things were made by Him; and without Him was not any thing made that was made. In Him was life." - John 1:3-4

Life comes only from Yahuah - the source of all life!

PROBLEMS WITH NATURALISTIC ORIGIN OF LIFE

  1. Miller-Urey problems: Wrong atmosphere; produced mostly tar; amino acids break down in oxygen
  2. Chirality: Life uses only left-handed amino acids; chemistry produces 50/50 mix
  3. Information: Where did genetic code come from?
  4. Minimum genome: Simplest cell needs ~300-400 genes - irreducible!
  5. Chicken-and-egg: DNA needs proteins; proteins need DNA
  6. Law of Biogenesis: Life only comes from life - never observed otherwise

The RNA World Hypothesis - Failed

Proposed that RNA could self-replicate and evolve into DNA/protein life. Problems:

REFLECT - Questions

1. List three problems with naturalistic origin of life:

12The Design Conclusion

RECEIVE - Following the Evidence

"For the invisible things of Him from the creation of the world are clearly seen, being understood by the things that are made, even His eternal power and Deity." - Romans 1:20

THE CUMULATIVE CASE FOR DESIGN

EvidencePoints To
Information in DNAIntelligent source
Irreducibly complex systemsPurposeful assembly
Molecular machinesEngineering
Fine-tuned biochemistryIntentional design
Failed origin-of-life experimentsSupernatural origin
Specified complexityIntelligent causation

Inference to Best Explanation

In any other field, these evidences would point to design:

DNA is all of these things! The evidence points to the Creator.

RESPOND - Final Reflection

1. How has studying advanced biology strengthened your faith in Yahuah as Creator?

2. What evidence would you share with someone who believes life arose naturally?